Welcome to the Glahn Group Website
David C. Glahn, PhD
How is brain structure and function changed in individuals with severe mental illness? Do genes that influence variation in brain structure and function also predispose these complex disorders? Will identifying the genes that influence brain anatomy, physiology and cognition provide a window in to the biological mechanisms leading to illnesses like major depression, bipolar disorder or psychosis? Can studying these traits lead to targeted treatments of these illnesses? These are the central questions addressed in Dr. David Glahn’s laboratory at the Olin Neuropsychiatry Research Center in the Institute of Living and at Yale University School of Medicine.
Our aim is to discover the genetic roots of neuroanatomic, neurophysiological and cognitive traits that are disrupted in major mental illnesses. To that end, we apply the theory, methodology and experimental designs from cognitive neuropsychology, functional and structural neuroimaging, and behavioral and molecular genetics in search of the causes of affective and psychotic disorders. As little is known about the genetic underpinnings of brain anatomy or physiology or cognitive ability, a major focus of our laboratory is to better understand the genetic underpinnings of brain structure and function in non-pathological individuals.