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Imaging

We use neuroimaging methods (1) to search for genes that influence brain anatomy and physiology and (2) to characterize the neuroanatomic and neurophysiological changes found in individuals with severe mental illnesses and their relatives. For the past few years, our neuroimaging research has focused exclusively on magnetic resonance methods to document structural and functional brain changes in individuals with schizophrenia or bipolar disorder and their relatives.  More specifically, we use anatomic (T1-weighted & T2-weighted) imaging, diffusion tensor imaging (DTI), and functional MRI (EPI, T2*-weighted) to explore the genetic influences on neuroanatomy and neurophysiology and how these traits are aberrant in major mental illnesses.

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Select Publications

  • Robinson JL, Monkul ES, Tordesillas-Gutiérrez D, Franklin C, Bearden CE, Fox PT, Glahn DC. Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation. Psychiatry Res. 2008 Nov 30;164(2):106-13.
  • Glahn DC, Laird AR, Ellison-Wright I, Thelen SM, Robinson JL, Lancaster JL, Bullmore E, Fox PT. Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol Psychiatry. 2008 Nov 1;64(9):774-81.
  • Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E. The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am J Psychiatry. 2008 Aug;165(8):1015-23.
  • Bearden CE, Glahn DC, Lee AD, Chiang MC, van Erp TG, Cannon TD, Reiss AL, Toga AW, Thompson PM. Neural phenotypes of common and rare genetic variants. Biol Psychol. 2008 Sep;79(1):43-57.
  • Glahn DC, Lovallo WR, Fox PT. Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns project. Biol Psychiatry. 2007 Jun 1;61(11):1306-9.
  • Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, Trakhtenbroit M, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Soares JC. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry. 2007 Jul 1;62(1):7-16.
  • Karlsgodt KH, Glahn DC, van Erp TG, Therman S, Huttunen M, Manninen M, Kaprio J, Cohen MS, Lönnqvist J, Cannon TD. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res. 2007 Jan;89(1-3):191-7.
  • Matsuo K, Glahn DC, Peluso MA, Hatch JP, Monkul ES, Najt P, Sanches M, Zamarripa F, Li J, Lancaster JL, Fox PT, Gao JH, Soares JC. Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Mol Psychiatry. 2007 Feb;12(2):158-66.
  • Pliszka SR, Glahn DC, Semrud-Clikeman M, Franklin C, Perez R 3rd, Xiong J, Liotti M. Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. Am J Psychiatry. 2006 Jun;163(6):1052-60.
  • Cannon TD, Glahn DC, Kim J, Van Erp TG, Karlsgodt K, Cohen MS, Nuechterlein KH, Bava S, Shirinyan D. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005 Oct;62(10):1071-80.
  • Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, Velligan DI. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp. 2005 May;25(1):60-9.
  • Glahn DC, Kim J, Cohen MS, Poutanen VP, Therman S, Bava S, Van Erp TG, Manninen M, Huttunen M, Lönnqvist J, Standertskjöld-Nordenstam CG, Cannon TD. Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage. 2002 Sep;17(1):201-13
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